Academic programs in the College of Applied and Natural Sciences are located in Carson Taylor Hall and George T. Madison Hall on the main campus as well as Reese Hall and Lomax Hall on the South Campus. In addition, numerous laboratory facilities in other buildings and at other site enhance the instruction of students. Biological Sciences and Human Ecology are located in Carson Taylor Hall. Nursing and Health Information Management are located in George T. Madison Hall.

The Center for Children and Families, the only such center in Louisiana approved by the Board of Regents, is operated by the School of Human Ecology. The Center encourages collaborative research, instruction and service that promote the well being of children and families. The Family and Child Studies Institute, one component of the Center, sponsors the endowed Bruce Everist Lecture Series. Another component, the Early Childhood Education Center, is a learning laboratory for three- and four-year-old children. Early Childhood Education students observe, student teach, and conduct research at the Center.

Agricultural Sciences and Forestry programs are located on the South Campus. Reese Hall and Lomax Hall provide classrooms, laboratories and office space. In addition, Lomax Hall houses research and student laboratories, greenhouses, and a display greenhouse for large plant specimens and exotic plantings. The 850 acre South Campus also has a Jersey-Holstein herd and dairy facilities which provide milk for the campus; a dairy processing plant which pasteurizes and packages milk, makes cheeses and butter, and produces ice cream; a meats laboratory which trains students in meat processing and marketing; and the equine facility.

The Louisiana Tech Equine Center provides facilities and animals for student instruction in all phases of horsemanship such as breeding, training, and nutrition. The center also provides recreational horseback riding sessions and is developing a therapeutic and handicapped horseback riding program.

Also located on the South Campus are numerous other facilities which support the agriculture and forestry programs: a sawmill, a dry kiln, wood utilization laboratories, a wood working shop, a weather station, a farm machinery shop, barns for livestock, fields, forests, nurseries, research vegetable and flower gardens, a 50-acre arboretum, and ponds.

University owned forestlands (800 acres) in North Louisiana and West Mississippi are used in the forestry education and research programs.