100: Introduction to Biomedical Engineering. 3-0-1. Development of the field of Biomedical Engineering, including job opportunities, the Biomedical Engineering Curriculum, professionalism and ethics, dimensions and units, Biomedical Engineering analysis and design.

202: BME Principles I. 0-1-1. Coreq., CHEM 102, BISC 225; Preq., MATH 230 or 240. Basic qualitative and quantitative principles of biomedical engineering are presented. The general field of biomedical engineering is reviewed with introduction of conservation and modeling concepts.

203: BME Principles II. 0-1-1. Coreq., BISC 227; Preq., BIEN 202. An introduction to the role of engineering in analyzing physiological systems and in designing devices and instrumentation to study and treat biomedical problems.

204: BME Principles III. 0-1-1. Preq., BIEN 203. A continued introduction to the role of engineering in analyzing physiological systems and in designing devices and instrumentation to study and treat biomedical problems.

301: Biomedical Fluid Mechanics and Biomedical Energy Transport. 0-3-3. Preq., BIEN 202, MATH 245 or 350, PHYS 202, BISC 321, and ENGR 222. The principles of fluid mechanics and thermal energy exchange (momentum and energy balances) in biomedical systems. Analysis of engineering and physiological systems and incorporation of these principles into design of such systems.

303: Biomedical Systems & Controls. 0-3-3. Preq., BIEN 204, ELEN 223, MATH 244, PHYS 202. Frequency domain transformation and analyses, control mechanisms, physiological control systems.

310: Introduction to Clinical Engineering. 3-2-3. Preq., BIEN 202. A foundation course in medical and clinical terminology, medical instrumentation, medical sciences, hospital procedure and medical practice from an engineering perspective.

320: Bioenergetics. 0-3-3. Preq., MATH 242, PHYS 201, BIEN 204. The student is introduced to the concept of bioenergetics-the thermodynamics of living systems. The laws of thermodynamics are emphasized and applied to biological systems.

325: Biomedical Engineering Instrumentation. 3-3-4. Preq., BIEN 204, ELEN 223, ENGL 102, PHYS 202, MATH 232 or 243. Analysis and design of Biomedical instrumentation. Basic circuitry, electronics and laboratory techniques including transducers, biopotentials, amplifiers, measurement and safety.

400: Biomedical Engineering Seminar. 3-0-1. Preq., Senior standing. Instruction and practice in conference-type discussions of technical and professional matters of interest to biomedical engineers.

401: Biomedical Mass Transport. 0-3-3. Preq., BIEN 301. The principles of mass balances and transport phenomena in biomedical systems. Analysis of engineering and physiological systems and incorporation of these principles into the design of such systems.

402: Biomedical Engineering Design I. 0-2-2. Preq., BIEN 325, 400, 401, 420; ENGL 303. Individualized design projects requiring integration and synthesis of prior engineering, life science, design and analytical skills. Utilization of the engineering design process and consideration of biomaterials, biomechanics, human factors, ethical and legal concerns, and oral and written communication skills.

403: Analysis and Design of Physiological Control Systems. 0-3-3. Preq., BIEN 325, 401, ELEN 321. Methods for analyzing and designing linear feedback systems. Physiological control mechanisms presented qualitatively and quantitatively. Design of systems involving physiological systems.

404: Biomedical Engineering Design II. 0-2-2. Preq., BIEN 402. A continuation of BIEN 402.

410: Clinical Engineering Internship. 20-20-6. Preq., BIEN 310 or equivalent and consent. A practical exposure to the health care delivery system. Application of engineering principles to problems unique to that system.

420: Biomaterials and Biomechanics. 0-3-3. Preq., BIEN 301, ENGR 220. Properties of living tissue. Biocompatibility. polymers, metals, and ceramics as biomaterials. Implants for hard and soft tissue. Fundamentals of biomechanics.

425: Advanced Biomedical Instrumentation Systems. 3-2-3. Preq., BIEN 325, or consent. Further analysis and design of biomedical instrumentation. Practical aspects of ideal and real operational amplifiers, and an introduction to microprocessor interfacing.

440: Computer Applications for Biomedical Engineers. 0-3-3. Preq., BIEN 202, ENGR 102. The course is designed specifically to training the student in the use of the digital computer for the solution of problems related to Biomedical Engineering. (G)

450: Special Topics. 1-4 semester hours credit. May be repeated for credit. Preq., senior standing and consent of instructor. Problems covering selected topics of current importance or special interest or need.

455: Biotechnology and Bioprocesses. 0-3-3. Preq., BIEN 301, 401. Introduction to biotechnology and bioprocesses. Microbiology and biochemical reactions are reviewed. Enzyme kinetics, microbial growth transport phenomena, and design of biochemical reactors are studied. Cross-listed with CHEN 455. (G)

500: Systems Physiology for Biomedical Engineers. 0-4-4. Preq. Graduate standing and permission of the instructor. Principles of human physiology, including cellular physiology, and the nervous, muscular, cardiovascular, and respiratory systems for engineers. Graduate core course.

501: Physiological Modeling I. 0-3-3. Preq., BIEN 500 and Differential Equations, or consent of instructor. Principles and applications of transport phenomena to biomedical systems and devices. Distributed, lumped, and lumped-distributed modeling. Graduate core course.

502: Biotransport Phenomena. 0-3-3. Preq., BIEN 501. A continuation of BIEN 501.

503: Physiological Modeling II. 0-3-3. Preq., BIEN 501 or consent of instructor. Application of mathematical modeling and engineering analysis to physiological components and systems. Feedback mechanisms for homeostasis. Computer project implementation. Graduate core course.

510: Bioinstrumentation. 0-4-4. Preq., Graduate standing and consent of instructor. Introduction to medical instrumentation systems, biosensors, biopotentials, signal conditioning, analog-to-digital conversion, and signal processing. Graduate core course.

515: Biosensors and Their Applications. 4-2-3. Permission of instructor. Introduction to biosensors in general with special emphasis on oxygen biosensors and their development. Surgical techniques and laboratory procedures for animal experimentation.

540: System Analysis and Mathematical Modeling of Physiological Phenomena. 0-3-3. Preq., permission of instructor. The course deals with the analysis of biological systems and the theory behind the development and solution of mathematical models for the description of biological system behavior.

550: Special Topics. 3 hours credit. Preq., Permission of instructor. May be repeated for credit. Selected topics dealing with advanced subjects in Biomedical Engineering.

551: Research and Thesis in Biomedical Engineering. 0-0-3. Preq., open to M.S. Graduate Students in Biomedical Engineering. Registration in any quarter may be for 3 semester hours credit or multiples thereof. Maximum credit allowed is six semester hours.

555: Practicum. 0-3-3 (6). Preq., 12 semester hours of graduate work. Analytical and/or experimental solution of an engineering problem; technical literature survey required; development of engineering research techniques.

556: Biomedical Engineering Internship. 20-0-6. Preq., permission of instructor. Graduate level internship emphasizing application of engineering design principles in a research, health care or rehabilitation setting.

560: Review of Assistive Technology in Rehabilitation. 0-3-3. Preq., permission of instructor. Study of physical disabilities and the rehabilitation process.

562: Rehabilitation Engineering & Assistive Technology I. 3-2-3. Preq., BIEN 560. Assessment and the development of engineering solutions in rehabilitation. Emphasis on seating and positioning, mobility, work, and activities of daily living.

563: Rehabilitation Engineering & Assistive Technology II. 3-2-3. Preq., BIEN 560. Assessment and the development of engineering solutions in rehabilitation. Emphasis on transportation and augmentative communication.

570: Artificial Intelligence Applications in Biomedical Engineering. 0-3-3. Preq., Prior introduction to artificial intelligence fundamentals. Artificial intelligence and expert systems application in medical and biomedical problems. Fundamental contributions of medical expert systems.

575: Artificial Neural Networks. 0-3-3. Presentation of foundational concepts and constructs used to analyze and characterize artificial neural network paradigms, their attributes, their applications and their implementations.

599: Graduate Seminar. 0-1-1. (Pass/Fail). Issues in graduate education. Presentations of current topics in research, teaching, and practice. May be repeated for credit.

651: Special Topics: Research. 0-0-3. Preq., open to Ph.D. candidates in Biomedical Engineering who have not completed their academic language and General Comprehensive Examination requirements. This course represents a limited research project, which will lead to a comprehensive and well-designed dissertation research proposal. A grade will be submitted at the end of each quarter for this course.