Leon Iasemidis, Ph.D., Director of CBERS, Professor and Rhodes Eminent Scholar Chair of Biomedical Engineering, The Brain Dynamics Laboratory, Location: Biomedical Engineering Center, 305; The EEG Laboratory, Location: Biomedical Engineering Center, 107 South
Department: Center for Biomedical Engineering and Rehabilitation Science (CBERS)
Learn more about Dr. Iasemidis.
Office: Biomedical Engineering Center, 203
Phone: (318) 257-5232
Fax: (318) 257-4000
Biomedical Signal Processing; Biomedical Imaging and Image Processing; Neural and Rehabilitation Engineering; Bioinformatics and Computational Biology, Systems Biology, and Modeling Methodologies; Therapeutic and Diagnostic Systems, Devices and Technologies, and Clinical Engineering; Biological and Medical Control Systems; Information Theory, Detection, Estimation, and Identification
Biosignal Processing and Dynamics from Humans and Animals; Biosystems Modeling and Control; Neuromodulation; Brain Dynamics; Brain and Heart (MEG and EEG, and ECG); Modeling of Epilepsy; Seizures Prediction and Control; Epileptogenic Focus Localization; Evaluation and Monitoring of Antiepileptic Treatment and Therapy; Seizure Control via Implanted deep brain stimulators (DBS); Differential Diagnoses (seizures vs. psychogenic non-epileptic seizures; epilepsy vs. metabolic encephalopathy); Mechanisms of Status Epilepticus (SE); Mechanisms of SUDEP (Sudden Unexplained Death in Epilepsy); Identification and Classification of Sleep Disorders; Depth of Anaesthesia studies
The EEG Laboratory
A facility for recording and long-term monitoring of spontaneous (awake, asleep) or evoked electroencephalographic (EEG) activity from the surface or interior of the human and animal brain. The Lab is equipped with three computerized EEG recording systems and has the capability to record from up to 128 electrode sites.
The Brain Dynamics Laboratory
A teaching and research computational facility with multiple computer stations, large (Terabyte) associated data storage units, fast access to supercomputing networks, professional software for data analysis. We develop novel in-house algorithms to investigate the spatiotemporal dynamics of electrical (EEG) and magnetic (MEG) signals from the brain of patients and animals, and computer simulation models, on the way into and out of crises. Epilepsy and progressive brain post-traumatic illnesses are among the dynamical disorders we concentrate upon. Conventional signal processing, image processing, and data mining techniques, as well as innovative measures of stability, complexity and information flow in networks of nonlinear systems, are utilized for long-term prediction of epileptic seizures. Adaptive feedback control has been implemented for their efficient and effective real-time control via neuromodulation. The research at the Brain Dynamics Lab also assists with the diagnosis, differential diagnosis and evaluation of the treatment of those and other brain dynamical disorders.
Over the years, our research has been supported by federal and state funding agencies (NIH, NSF, DoD, VA, DARPA, the Science Foundation of Arizona), private foundations (American Epilepsy Research Foundation, the Whitaker Foundation) and other organizations (Cyberonics Inc.)
Associate Center Director
Mark DeCoster, Ph.D., Associate Director of CBERS, Professor of Biomedical Engineering, Institute for Micromanufacturing
The Cellular Neuroscience Lab, Location: Biomedical Engineering Center, 235 and 210; Institute for Micromanufacturing, 215
Dr. DeCoster’s laboratory is designed for biochemical and digital imaging analysis of cellular events in the brain. Currently planned activities include brain cell inflammatory responses, digital imaging of apoptosis in normal and brain tumor cells and response of brain glial cells to injury. Major equipment includes PC- and Mac-based imaging workstations (4); motorized inverted fluorescence microscope with a digital camera (Leica).
Administrative Coordinator 4
Dr. Arumugam’s research interests are carbon nanomaterial synthesis and characterization, nano-bio-neuro electrochemical sensors for point-of-care diagnostics, biomedical coatings, advanced oxidation processes for water treatment, and electrodes for energy storage. The current research focus is to engineer novel electrode geometries and material compositions using micro-nanofabrication techniques and to advance the chemical neuroscience field for brain disorder treatments.
Dr. Bishop’s research interests are theoretical and computational molecular biology, with a particular emphasis in molecular modeling and molecular dynamics simulations of proteins and DNA. The current focus is on developing workflows and a scientific gateway for atomic and coarse-grained modeling of DNA, nucleosomes, and chromatin.
Mary Caldorera-Moore, Ph.D., Associate Professor of Biomedical Engineering
Therapeutic Micro- and Nanotechnology Biomaterial Laboratory, Location: Biomedical Engineering Center, 207
Dr. Caldorera-Moore’s lab focuses on the development of innovative approaches to long-term drug release and targeted cell-specific drug delivery. Our research combines microscale and nanoscale technologies with intelligent biomaterials to create new and improved ways to deliver therapeutic agents to target sites in the body. Research in the lab focuses on the design, fabrication, characterization, and use of advanced micro/nano biosystems for targeted delivery.
William Campbell, Ph.D., Associate Dean for Research at the College of Applied and Natural Sciences and Director of the School of Biological Sciences, Location: PML, 913
Dr. Campbell’s research interests are protein analysis, and environmental physiology/biochemistry.
Sumeet Dua, Ph.D., Associate Vice President for Research and Partnerships
Location: Wyly Tower, 1642
Dr. Dua’s research specialization is Data Mining, Computational Decision Support, Structural Bioinformatics Biological System Modeling, Multi-modality Fusion, and Biomedical Imaging. Dr. Dua’s laboratory designs and implements high-performance algorithms and software “Cybertools” for data mining and computerized learning. These algorithmic tools discover, classify, and exploit trends, patterns, and anomalies in large volumes of data. The laboratory also develops unsupervised and supervised algorithmic routines for sequential, temporal, and associative pattern discovery in spatiotemporal spaces. These algorithmic routines have applications in gene expression and protein sequence/structure datasets based analytics (supported by NIH). Recent efforts have focused on extracting and isolating protein structural features that sustain invariance in evolutionary-related proteins through the integrated and localized analysis of hydrophobicity and other physicochemical properties. Dr. Dua’s team is currently investigating such methods to computationally characterize biological resistance to freezing, desiccation, and radiation, to improve technologies for the detection and sampling of microorganisms under conditions similar to those found on the surface of Mars. Other applications of such data-mining methods include automated detection, identification, and tracking of patterns of (hostile) “targets” using multi-sensor satellite imagery and network data (for the U.S. Air Force).
Sven Eklund, Ph.D., Associate Professor of Chemistry
Location: Carson-Taylor Hall, 331
Dr. Eklund’s research interests involve designing and implementing extracellular biosensors for monitoring cell metabolism in various environments. Sensors are based on electrochemical or fluorescent signals that are used to measure multiple analytes concurrently in real-time (glucose, lactate, oxygen, pH, Ca2+, K+, etc.). He also is exploring the electrodeposition of thin films of tantalum metal from ionic liquids for coating of medical implants.
Katie Evans, Ph.D., Associate Dean for Strategic Initiatives, Director of Mathematics and Statistics and Online Programs, Entergy LP&L/NOPSI #3 & #4 Associate Professor of Mathematics and Statistics
Location: Bogard, 201C
Dr. Katie Evans is the Entergy LP&L/NOPSI Endowed Associate Professor of Mathematics and Statistics, the Associate Dean for Strategic Initiatives, and the Director of Mathematics and Statistics and Online Programs. She is the Director of the Integrated STEM Education Research Center (ISERC) and the Director of the Office for Women in Science and Engineering. She earned her Ph.D. in Mathematics and M.S. in Mathematics at Virginia Tech, Blacksburg, VA. Her research interests include distributed parameter control modeling and simulation, dynamic modeling of physical systems, and STEM education. Her research has been funded by the NSF, AFRL, and LA-BOR. She is a member of the IEEE, MAA, SIAM, and ASEE.
Rebecca Giorno-McConnell, Ph.D., Associate Professor of Biological Sciences
Location: Carson-Taylor Hall, 131
Dr. Giorno-McConnell’s research interests involve the protein coatings that encase bacterial spores and allow them to survive harsh environments. She studies the assembly of the coat and the exosporium in the spore-forming bacteria Bacillus anthracis. Her work is done in the attenuate Sterne strain of B. anthracis.
Levi Good, Ph.D., Assistant Professor of Biomedical Engineering, The Neural Systems Lab, Biomedical Engineering Center, 133.
Our research focuses on neural engineering, including the neural recording of rodent models of disease and injury, digital signal processing, evoked potentials, and neuromodulation. The goal of our research is to develop novel diagnostic and therapeutic modalities for epilepsy, and other neurological disorders such as autism, traumatic brain injury and inherent neurometabolic disorders.
Eric Guilbeau, Ph.D., Professor Emeritus of Biomedical Engineering
Dr. Guilbeau develops thermoelectric methods for applied biotechnology and biosensors. Activities include the development of microfluidic devices that utilize thermoelectric sequencing by incorporation methods to sequence DNA for SNP detection and to detect DNA hybridization events. He also uses thermoelectric methods to design novel biosensors for the detection of biologically active substances that are important for normal and abnormal biological and physiological function and to create gas sensors that can detect biologically important substances in the breath or toxic substances in the environment. Both experimental and modeling approaches are used as part of the design, development and characterization activities.
Patrick Hindmarsh, Ph.D., Associate Professor of Biological Sciences
Location: Carson-Taylor Hall, 205
Dr. Hindmarsh’s research interests are Mycology/Microbiology, Molecular Biology, Chromosomal Loss and Genome Regulation, and Virulence Activation.
Bryant Hollins, Ph.D., Lecturer of Biomedical Engineering
The Oxidative Stress Research Lab, Location: Biomedical Engineering Center, 211
The oxidative stress research lab studies proteins that are prone to oxidative stress in neurodegenerative diseases. One of the things we seek to determine is the interplay between these proteins and other biomacromolecules. The ultimate goal is to discover new protein therapeutic targets in neurodegenerative diseases, such as Alzheimer’s disease.
Steven Jones, Ph.D., Associate Professor and Program Chair of Biomedical Engineering
The Biofluid Mechanics Laboratory, Location: Biomedical Engineering Center, 206
Dr. Jones’ research interests stem from biomedical applications of fluid dynamics. Applications include the improvement of Doppler ultrasound instruments for velocity measurement, modeling of pressure-flow relationships in the vascular access grafts used for dialysis, and modeling of the effects of transport and flow on the positive feedback and negative feedback control mechanisms for platelet activation and adhesion. The laboratory includes laser Doppler velocimetry equipment, a cone-in plate viscometer, a data acquisition computer, various PC computers, ultrasonic equipment, an anti-vibration table, a spectrum analyzer, physiological pressure transducers, Carolina Medical electromagnetic flow meters, a transit time flow meter, model manufacturing facilities, a single syringe infusion pump and a 10-syringe infusion pump.
Xiyuan Liu, Ph.D., Assistant Professor of Statistics
Mathematics and Statistics, Location: Nethken Hall, 223
Our research focuses on the application and theoretical improvement of machine learning models. The research area involves bioinformatics, longitudinal data analysis, Bayesian model, neural network, graphic model, generalized linear model, and discriminative model.
Dr. Lvov’s laboratory focus is on developing nanotechnology including nanoassembly of ultrathin organized films, bio/nanocomposites, nano/construction of ordered shells on tiny templates (drug nanocapsules, shells on microbes and viruses), clay nanotubes for controlled release of bioactive agents. Yuri Lvov was among the pioneers of the polyelectrolyte layer-by-layer (LbL) assembly, a nanotechnology method which, after the first papers in 1993, was followed by many thousands of publications by researchers from all over the world. LbL nanoassembly has already been used in industrial applications for eye lens modification, improvement of cellulose fiber for better fabric and paper, microcapsules for insulin sustained release, cancer drug nanocapsules, and others. The basic principle of our research is nanoarchitectonic, and we develop: 1) nanoassembly approach in biomimetic engineering; 2) smart nanocontainers, nanocapsules and nanotubes for drug targeted and controlled delivery; stem cell and microbe encapsulation; 3) integrated nano/micro/macro-organized tissue scaffolds (in collaboration with Mark DeCoster and David Mills).
The BioMorph Laboratory
Dr. Mills’ BioMorph Laboratory is used for designing novel and dynamic nanofilms (biodegradable, bioactive, micropatterned) for cell adhesion, differentiation and functionality; nanoassembly for dental & orthopedic implants; layer-by-layer assembly for cell encapsulation; application of nanoscale topographic and chemical cues for controlling chondro- and osteogenesis; understanding complex soft tissue modeling during development and remodeling in response to altered joint mechanics; structure-function relationships in TMJ soft tissues, engineering tissues for TMJ repair or replacement.
Teresa A. Murray, Ph.D., Associate Professor of Biomedical Engineering
The Integrated Neuroscience and Imaging Laboratory, Location: Biomedical Engineering Center, 132
Dr. Murray’s research goals are to expand the reach and functionality of micro-optics for neuroscience applications and to create living bio-optical systems using molecular and cellular engineering. She plans to incorporate electrodes for field potential recording into implantable micro-optic devices and perform time-course experiments. Her main aim is to connect receptor dynamics, neural circuit function and behavior through in vivo fluorescence imaging, neural recording, and behavioral experiments. This concerted approach will streamline experiments, enable unparalleled comparative analysis and elucidate connections not possible using multiple, discrete experiments. Additionally, this system will facilitate studies of neural dynamics and behavior in drug addiction, neurodegeneration, and stem cell therapy. While her focus has been on neuroscience, the tools and techniques she has developed have broad applications for life sciences and translational research.
Stanley A. Napper, Ph.D., Professor Emeritus of Biomedical Engineering
Dr. Napper participates at various levels in Engineering Education research. Earlier research activities have included Biomedical Engineering applications of artificial intelligence and mathematical modeling of physiological systems.
Dr. Nestorova’s research interests are focused on the development of lab-on-a-chip technologies for integrated genomics and proteomics analysis and investigation of microRNAs function in the post-translational regulation of gene expression. Research activities involve the development of microfluidics system for ultrasensitive purification and quantification of microRNAs from low cell number and identification of novel microRNAs that regulate the activity of DNA repair proteins.
Dr. Newman’s research interests center around understanding gene expression during cellular differentiation and transformations. She has a particular interest in using stem cells to better understand patterns of differentiation in mammalian development using a variety of molecular biology techniques, imaging, and collaborations with people in areas of biomedical engineering.
Randal E. Null, Ph.D., Professor of Biomedical Engineering
Location: Biomedical Engineering Center, 228
Dr. Null provides leadership to Louisiana Tech University and the State of Louisiana by providing national quality higher education in research and development areas that improve energy systems, cyberspace security, medical technology, fundamental nanotechnology processes, biological/chemical/physical sensors, and other cutting-edge science and technology.
D. Patrick O’Neal, Ph.D., Associate Professor of Biomedical Engineering
The Nano Particle Training and Manufacturing Laboratory, Location: Biomedical Engineering Center, 136
Dr. O’Neal’s laboratory focuses on biomedical optics and nanotechnology for the support of cancer detection, treatment, and management. Current activities include optical sensing and imaging, development of optically-active nanoparticles for detection, imaging, and drug delivery, surface-enhanced Raman spectroscopy for bio-assays, and nanomaterial toxicity assessment. Major equipment includes a PTI Dual Monochromator Fluorescence Spectrometer, fiber optic equipment (Thor Labs), a Beckman Coulter DU-800 UV-Vis Spectrophotometer, and a Raman Systems R3000-HR Raman Spectrometer: a portable system with a 785nm laser.
Dr. Poh’s research interests involve developing diagnostic and therapeutic applications that possess adept properties and functions to target inflammatory diseases, cancer and/or infectious pathogens. We also prepare a variety of small molecules to macroscale architectures such as multi-functional nanoparticles, nanogels, liposomes, and nanofibers. Our research focuses on chemical syntheses, characterization and the understanding of chemical, physical, biological properties, and application.
Adarsh D. Radadia, Ph.D., Associate Professor of Chemical Engineering
Bio-Nanomaterials Interface Design & Applications Laboratory
Location: Biomedical Engineering Center, 218 and 220C
Dr. Radadia specializes in medical diagnostics for bacteria, viruses, and relevant protein and nucleic acid biomarkers; bio-physical-chemical interactions at the surface of carbon nanomaterials, especially graphene and nanodiamonds.
Shabnam Siddiqui, Ph.D., Research Assistant Professor of CBERS
Location: Biomedical Engineering Center, 202
Conducting Research with Dr. Leon Iasemidis in RII Track-2 FEC: Probing and Understanding the Brain: Micro and Macro Dynamics of Seizure and Memory Networks
Dr. Siddiqui’s research focus on the development of mathematical and computational models for studying electrical and chemical properties of Nanomaterials enabled electrodes for applications in biological, neuro-chemical sensing and energy storage. Other interests include the development of teaching tools, methods, and strategies to improve teaching quality in STEM fields, and theoretical investigation of quantum adiabatic techniques and quantum error-correcting methods.
Kirk St. Amant, Ph.D., Professor and Endowed Chair in Technical Communications, Usability Studies Center, Location: George T. Madison Hall, 278
Shengnian Wang, Ph.D., Associate Professor of Chemical Engineering, The Biomolecule Nanoengineering and Cell Therapy Laboratory
Location: Institute for Micromanufacturing, 112
Dr. Wang’s research interests involve cell therapy and the nanoengineering of biomolecules. Activities include single DNA dynamics, microrheology and flow-guided assembly using biopolymers along with the development of nanoparticles and nanodevices for non-viral cell therapy. Microfluidics and nanofluidics are integrated to offer such studies excellent platforms. Major equipment includes a CNC mill, an electroporator, a fluorescence microscope, and an atomic force microscope.
James Cardelli, Ph.D.
CEO Segue Therapeuics LLC
1501 Kings Highway
Shreveport, LA 71130
As a neonatal nurse practitioner, Dr. Eklund has decades of experience in the medical management of ill or premature infants in the Neonatal Intensive Care Setting. Prior to entering the neonatal field, her clinical focus was in adult critical care, especially in the cardiovascular specialty. Her current research interest is in improving the quality of care for the vulnerable population by combining current technologies with relevant neonatal specific knowledge. The aim is to focus on innovative ideas, which can lead to better modalities for care providers to improve patients’ physiological and neurobehavioral outcomes.
Other areas of interest include studying the Global Neonatal Workforce and improving health education and policies that impact neonatal practice and neonatal outcomes worldwide. She collaborates with the Council of International Neonatal Nurses to conduct international research and participates in designing international initiatives.
She has authored textbook chapters in neonatal nursing in the United States and edited the first comprehensive Neonatal Nursing textbook in Japan. Her research in Advanced Practice Nursing, Global Neonatal Workforce, and Neonatal Scope of Practice has been published nationally and internationally. Her publications, including multiple peer-reviewed articles, have appeared in journals in medicine and surgery in addition to nursing.
Pradeep Garg, Ph.D.
Center for Molecular Imaging and Therapy (CMIT) – Shreveport
Subsidiary of Biomedical Research Foundation of Northwest Louisiana
Details: Center for Molecular Imaging & Therapy
Edward Glasscock, Ph.D.
LSU Health Sciences Center – Shreveport
Department of Cellular Biology and Anatomy
1501 Kings Highway
Shreveport, LA 71130
Dr. Glasscock’s research focuses on the molecular and electrophysiological mechanisms that contribute to neurocardiac and cardiorespiratory dysfunction in mouse models of epilepsy and sudden unexplained death in epilepsy (SUDEP). His lab seeks to answer the question of how ion channelopathies causing seizures can give rise to faulty brain-heart-lung interactions leading to SUDEP, the most common cause of mortality in epilepsy. To explore these questions, the lab studies genetic mouse models of epilepsy, utilizing a wide array of in vivo, ex vivo, and in vitro electrophysiological techniques, pharmacology, histology, and molecular analyses.
Anne Hollister, M.D.
Retired Orthopedic Surgeon, LSU Health Sciences Center – Shreveport
Christina Ledbetter, Ph.D.
Pharmacology and Neuroscience
Louisiana State University Health Sciences Center – Shreveport
Georgios Matthaiolampakis, Ph.D.
Assistant Professor of Pharmaceutics
Basic Pharmaceutical Sciences
School of Pharmacy
University of Louisiana at Monroe
Dr. Matthaiolampakis is using polymer-based nanomedicine to promote scientific knowledge in cancer treatment. His lab integrates nanotechnology, imaging science, gene therapy, and cancer biology. Based on pharmaceutical sciences, his research on drug delivery, using modern or more traditional approaches, aims to improve pharmacokinetic, biodistribution and absorption, water solubility and efficacy for smaller and bigger molecules.
The overarching goals for Dr. Matthaiolampakis’ lab are:
– To generate approaches that combine gene therapy with traditional chemotherapy to overcome chemoresistance and inhibit metastasis.
– To develop effective and safe agents for the treatment of prevalent human cancers, such as pancreatic, colon, skin, breast, and lung cancer
– To improve drug targeting utilizing single or dual targeted nanomedicines, by recognizing the dynamic tumor microenvironment and cancer biology.
-To promote student-oriented research to help young scientists transition from the undergraduate to graduate level and beyond with knowledge in analytical methodology, gene therapy, and cancer treatment approaches.
Hai Sun, M.D., Ph.D.
Neurosurgery, Biomedical Engineering
Louisiana State University Health Sciences Center – Shreveport
Faculty in Neurosurgery, Pharmacology, Toxicology and Neuroscience, LSUHSC, 2015 – present
Electrophysiological and Optogenetic studies in Sudden Unexplained Death in Epilepsy (SUDEP) mice model.
o Investigations of structural and functional connectivity abnormalities in patients with neurological disorders including, traumatic brain injuries, multiple sclerosis, and epilepsy.
o Investigation of cortical networks with imaging and electrophysiological techniques in patients with epilepsy.
o Investigating image and electrophysiology-based seizure foci localization.
Oregon Health & Science University 2007 – present
o Designed and implemented a murine focal neocortical epilepsy model via viral vector induced over-expression of adenosine kinase (ADK) in cortical astrocytes. o Employed an advanced optic coherence tomography (OCT) system to study the physiological changed in cortical neurovascular changes in the epilepsy foci in this model.
o Processed EEG and 3-D imaging data using software or Matlab source codes. Advisors: Ricky Wang, Ph.D. and Detlev Boison, Ph.D.